There are many computer programs that model the consequences to built infrastructure when subject to explosive blast loads; however, the majority of these do not account for the uncertainties associated with system response or blast loading. This paper describes new software – called “Blast-RF” (Blast Risks for Facades) – that incorporates existing blast-response software within an environment that considers threat/vulnerability uncertainties and variability via probability and structural reliability theory. This allows the prediction of likelihood and extent of damage and/or casualties; information which will be useful for risk mitigation considerations, emergency service’s contingency and response planning, collateral damage estimation and post-blast forensic analysis.